Cicatricial Pemphigoid Autoantibodies React with Multiple Sites on the BP180 Extracellular Domain
نویسندگان
چکیده
منابع مشابه
Multiple mucosal involvement in cicatricial pemphigoid.
Mucous membrane pemphigoid includes chronic autoimmune sub-epithelial blistering diseases that predominantly affect mucous membranes, with varying combinations of oral, ocular, cutaneous, genital, nasopharyngeal, oesophageal and laryngeal lesions. The case is reported of a man with multiple manifestations of mucous membrane pemphigoid. A 53-year-old male presented at our Department with a 4-yea...
متن کاملBullous pemphigoid of childhood: autoantibodies target the same epitopes within the NC16A domain of BP180 as autoantibodies in bullous pemphigoid of adulthood.
BACKGROUND Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease of the elderly that rarely occurs in children. Most adult BP serum samples react with epitopes within the NC16A domain of BP180, a glycoprotein of the cutaneous basement membrane zone. OBJECTIVES To characterize the autoimmune response in childhood BP using recombinant forms of BP180 and to determine the subcl...
متن کاملSerum Levels of Autoantibodies to BP180 Correlate With Disease Activity in Patients With Bullous Pemphigoid
Main Outcome Measures: Disease activity, serum levels of autoantibodies to BP180, and titers of anti– basement membrane zone autoantibodies were assayed before initiation of treatment and 4 and 8 weeks later. Reactivity to BP180 was analyzed by enzyme-linked immunosorbent assay using a recombinant form of BP180 NC16A. Titers of anti–basement membrane zone autoantibodies were assayed by indirect...
متن کاملBP180 as the common autoantigen in blistering diseases with different clinical phenotypes.
Bullous pemphigoid antigen 180 (BP180, type XVII collagen) is a transmembrane hemidesmosomal glycoprotein of basal keratinocytes that spans the lamina lucida of the dermal-epidermal junction. Five autoimmune subepidermal blistering diseases are associated with an immune response to BP180, including bullous pemphigoid (BP), pemphigoid gestations (PG), cicatricial pemphigoid (CP), lichen planus p...
متن کاملAssociation of Autoantibodies to BP180 with Disease Activity in Greek Patients with Bullous Pemphigoid
39 bullous pemphigoid (BP) patients were studied to assess the clinical significance of anti-BP180 and anti-BP230 circulating autoantibodies of BP and correlate their titers with the clinical scores of the BP Disease Area Index (BPDAI) and the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) as well as with the intensity of pruritus measured by the BPDAI pruritus component. All paramete...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1996
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12329728